Full cast of The Epic Tales of Captain Underpants

Nat Faxon

Captain Underpants / Mr. Krupp (voice)

39 episodes

Jay Gragnani

Harold (voice)

39 episodes

Ramone Hamilton

George (voice)

39 episodes

Sean Astin

Narrator (voice)

39 episodes

Peter Hastings

Comic Narrator (voice)

39 episodes

Jorge Diaz

Melvin (voice) / Melvin / Melvinborg (voice)

39 episodes

Dayci Brookshire

Jessica / Dressy (voice)

39 episodes

Evan Kishiyama

Steve 'Gooch' Yamaguchi (voice)

39 episodes

Erica Luttrell

Erica (voice) / Grace Wain (voice) / Erica / Plungerina (voice) / Werica Ang (voice)

8 episodes

Laraine Newman

Ms. Ribble (voice) / Ms. Ribble / Dr. Mentor (voice) / Ms. Ribble / Queen Zombee (voice) / Female Cop (voice) / Dr. Mentor / Ms. Ribble (voice) / Ms. Ribble / Malison Saurus (voice)

8 episodes

David Koechner

Mr. Meaner (voice) / Mr. Meaner / Flabby Flabulous (voice) / Mr. Meaner / Mr. Neamer / Brainy Blabulous (voice) / Mr. Meaner / Sergeant Boxers (voice) / Dr. Will Boryew (voice)

6 episodes

Patty Mattson

Miss Anthrope (voice) / Miss Anthrope / Clogneta (voice) / Miss Anthrope / Chalice Aristocrab (voice)

6 episodes

Clancy Brown

Mr. Ree (voice) / Mr. Ree / Splotch (voice)

4 episodes

Eric Bauza

Rap Talkwell (voice) / Robius (voice) / Rap Talkwell / Mr. Gigglenose (voice)

3 episodes

Kevin Michael Richardson

Diddlysaurus / The Schmoozer (voice) / Diddlysaurus / Fingers (voice) / George's Dad / Dune Buggy (voice)

3 episodes

Mindy Sterling

Melvin's Mom (voice) / Harold's Mom / Melvin's Mom (voice)

3 episodes

Nolan North

Nanozero / Flash Flood (voice) / Cash Networth / Salamangler (voice) / Cash Networth / Lee Dingman (voice)

3 episodes

Tress MacNeille

Ms. Hurd / DJ Drowsy Drawers (voice) / Ms. Hurd (voice)

2 episodes

Maggie Wheeler

Ms. Yewh / TP Mummy (voice) / Lunch Lady (voice)

2 episodes

Trevor Devall

Smartsy Fartsy (voice)

2 episodes

Fred Tatasciore

Keithicus / Rippedicus / Guardicus (voice) / Furculees / Chief Hairococha (voice)

2 episodes

Max Koch

Laserlightmare (voice) / Hank (voice)

2 episodes

Steve-O

Lane Junkston (voice)

1 episode

Maurice LaMarche

Tubbadump (voice)

1 episode

Kari Wahlgren

Mayor Hoppy McChapper (voice)

1 episode

Stephen Root

Mr. Fyde / Avacadwoe / Hush Muffleman (voice)

1 episode

Brennan Murray

Bo Hweemuth / Claylossus (voice)

1 episode

Jim Rash

Señor "Jerry" Citizen (voice)

1 episode

John DiMaggio

Smelly Socktopus / Suds Latherman (voice)

1 episode

Rob Riggle

Theodore 'Ted' Murdsly (voice)

1 episode

Tudi Roche

Bernice Krupp (voice)

1 episode

Paul Rugg

Vert Ladderfeller III / Altitooth / Bivouac Ladderfeller (voice)

1 episode

Lewis Black

Ragely J. Snarlingtooth (voice)

1 episode

Thomas F. Wilson

Major Messy / Camoflush (voice)

1 episode

Dawn Wells

Gumbalina Toothington (voice)

1 episode

Toby Huss

Caesar / Cruelius Sneezer (voice)

1 episode