Full cast of The Drew Barrymore Show

Drew Barrymore

Self - Host

397 episodes

Ross Mathews

Self - Co-Host / Self

89 episodes

Cameron Diaz

Self

4 episodes

Gwyneth Paltrow

Self

3 episodes

Ellie Kemper

Self - Guest

3 episodes

Danny Seo

Self / Self - Guest

3 episodes

Demi Lovato

Self

3 episodes

Tyra Banks

Self

2 episodes

Mariska Hargitay

Self

2 episodes

Reese Witherspoon

Self

2 episodes

Lucy Liu

Self

2 episodes

David Arquette

Self

2 episodes

Jason Biggs

Self

2 episodes

Nischelle Turner

Self

2 episodes

Giada De Laurentiis

Self

2 episodes

Jenna Ortega

Self - Guest / Self

2 episodes

Yara Shahidi

Self

2 episodes

Pilar Valdés

Self - Guest

2 episodes

Natalie Portman

Self - Guest

2 episodes

Adam Sandler

Self

1 episode

Gabrielle Union

Self

1 episode

Christian Siriano

Self

1 episode

Billy Porter

Self

1 episode

Billy Eichner

Self

1 episode

Derrick Barnes

Self

1 episode

Jennifer Aniston

Self

1 episode

Wayne Brady

Self

1 episode

Ali Wentworth

Self

1 episode

Charlize Theron

Self

1 episode

Paris Hilton

Self

1 episode

José Andrés Puerta

Self

1 episode

Hugh Grant

Self

1 episode

Olivia Rodrigo

Self - Guest

1 episode

Sophia Bush

Self

1 episode

Nicole Lapin

Self

1 episode

Sabrina Carpenter

Self

1 episode

Carla Lalli Music

Self

1 episode

Scarlett Johansson

Self - Guest

1 episode

Molly Shannon

Self

1 episode

Michael Vartan

Self

1 episode

Billie Eilish

Self

1 episode

Cedric the Entertainer

Self

1 episode

Kevin Frazier

Self

1 episode

Awkwafina

Self

1 episode

Fat Joe

Self

1 episode

Fran Drescher

Self

1 episode

Benito Skinner

Self

1 episode

Tiki Barber

Self

1 episode

Jenny Mollen

Self

1 episode

Eddie Murphy

Self

1 episode

Courteney Cox

Self

1 episode

Neve Campbell

Self

1 episode

Kathryn Hahn

Self

1 episode

Jane Levy

Self

1 episode

Amy Schumer

Self

1 episode

Violet Young

Self

1 episode

Keanu Reeves

Self

1 episode

Aubrey Plaza

Self

1 episode

Chloë Grace Moretz

Self - Guest

1 episode

Andra Day

Self

1 episode

Erin Napier

Self

1 episode

Ben Napier

Self

1 episode

Ben Platt

Self

1 episode

Samantha Bee

Self

1 episode

Kristen Wiig

Self

1 episode

Jamie Dornan

Self

1 episode

Annie Mumolo

Self

1 episode

Steven Spielberg

Self

1 episode

David Letterman

Self

1 episode

Jimmy Fallon

Self

1 episode

Keith Morrison

Self

1 episode

Savannah Guthrie

Self

1 episode

Chelsea Handler

Self

1 episode

Rita Ora

Self

1 episode

Kat Dennings

Self

1 episode

Garcelle Beauvais

Self

1 episode

Jennifer Love Hewitt

Self

1 episode

Abigail Cowen

Self

1 episode

Regina Hall

Self

1 episode

Lana Condor

Self

1 episode

Jill Kargman

Self

1 episode

Priyanka Chopra Jonas

Self

1 episode

Lionel Richie

Self

1 episode

Dakota Johnson

Self

1 episode

Ralph Macchio

Self

1 episode

Regé-Jean Page

Self

1 episode

Phoebe Dynevor

Self

1 episode

Suzanne Somers

Self - Guest

1 episode

Jet Tila

Self - Guest

1 episode

Iris Apatow

Self

1 episode

John Cho

Self

1 episode

Lea Michele

Self

1 episode

Millie Bobby Brown

Self - Guest

1 episode

Eva Longoria

Self

1 episode

Damson Idris

Self

1 episode

Dylan Mulvaney

Self

1 episode

Lewis Howes

Self

1 episode

Shania Twain

1 episode

Julia Fox

1 episode

Bob Odenkirk

Self - Guest

1 episode

Nicole Avant

1 episode

Cleo Wade

1 episode

Reggie Watts

1 episode

Mikel Welch

1 episode

Barbara Costello

1 episode

Jane Fonda

Self

1 episode

Gigi Hadid

Self - Guest

1 episode

Tan France

Self - Guest

1 episode

John Stamos

1 episode

Theresa Caputo

1 episode

Bobby Berk

1 episode

Ree Drummond

Self

1 episode

Chris Appleton

Self

1 episode

Daymond John

1 episode

Sarah Sherman

Self

1 episode

Fred Savage

Self - Guest

1 episode

Elisha Williams

Self - Guest

1 episode

Noah Schnapp

Self

1 episode

Seth MacFarlane

Self - Guest

1 episode

Rachel Zegler

Self - Guest

1 episode

Whoopi Goldberg

Self - Guest

1 episode