Full cast of Samantha Who?

Christina Applegate

Samantha Newly

35 episodes

Jennifer Esposito

Andrea Belladonna

35 episodes

Kevin Dunn

Howard

35 episodes

Melissa McCarthy

Dena

35 episodes

Tim Russ

Frank

35 episodes

Barry Watson

Todd

35 episodes

Jean Smart

Regina Newly

35 episodes

Rick Hoffman

Chase Chapman

9 episodes

Stephen Rannazzisi

Seth

6 episodes

Billy Zane

Winston Funk

5 episodes

Kiele Sanchez

Chloe

4 episodes

James Tupper

Owen

4 episodes

Joy Osmanski

Tracy

4 episodes

McKinley Freeman

Tony Dane

4 episodes

Eliza Coupe

Willow

2 episodes

Eddie Cibrian

Kevin

2 episodes

Dana Sorman

Jerri

2 episodes

Adam Devine

Tyler

2 episodes

Nakia Burrise

Kerry Hall

1 episode

Timothy Olyphant

Winston Funk

1 episode

Natasha Leggero

Woman Customer

1 episode

Anthony Anderson

Rafael Grace

1 episode

Mark Ballas

Mateo Romero

1 episode

Tony Hale

Andy Adams

1 episode

Teddy Sears

Brad

1 episode

Rebecca Wisocky

Lindsey

1 episode

Brett Rickaby

AA Leader

1 episode

Beth Littleford

Audrey Rhodes

1 episode

Ryan Carnes

Brent

1 episode

Cybill Shepherd

Paula Drake

1 episode

Mary-Kate Olsen

Natalie

1 episode

James Patrick Stuart

Bill Jacobs

1 episode

Andre Ware

Mac Fresh

1 episode

Jerry O'Connell

Craig

1 episode

Miranda May

13-Year-Old Dena

1 episode

William Abadie

Rene

1 episode

Jelynn Sophia

Angry Woman

1 episode

Dan Thiel

Dave

1 episode

Adam Jennings

Barista

1 episode

Jill Talley

AA Female Leader

1 episode

Frank Maharajh

Dr. Kegoshian

1 episode

Jamison Haase

Vic

1 episode

B.J. Clinkscales

Waiter

1 episode

Jessica St. Clair

Valerie

1 episode

Gerald Downey

Paul

1 episode

Curt Cornelius

Trey

1 episode

Amanda Young

Paul's Wife

1 episode

Kara Taitz

Bridesmaid

1 episode

Ryan Carlberg

Jason

1 episode

Rand Holdren

Ryan

1 episode

Sarah Spiegel

Young Woman

1 episode

Todd Grinnell

Nathan

1 episode

Johanna Braddy

Teenage Samantha

1 episode

Jagger Chase

Kid

1 episode

Kelsey Lee Smith

Young Samantha

1 episode

Marilyn Sue Perry

Cashier

1 episode

Arshad Aslam

Barista

1 episode

Reggie Jordan

Flower Delivery Guy

1 episode

Timon Kyle Durrett

Russ

1 episode

Tanya Bond

Girl

1 episode

Ossie Mair

Driver

1 episode

Jaclyn Kerhulas

Sign Language Interpreter

1 episode

Morgan Murphy

Woman Protestor

1 episode

Jim Rash

Artist

1 episode

Jonathan Schmock

Hipster

1 episode

Brandon Ford Green

Guy

1 episode

Ian Duncan

Cameron

1 episode

Soledad Campos

Woman

1 episode

Tony Winters

Man

1 episode

Melody Butiu

Nurse

1 episode

Brian Catalano

Orderly

1 episode

Sarah Rafferty

Kayla Kaminski

1 episode

Gregory Franklin

Announcer

1 episode

Rachel Cannon

Carol

1 episode

Phoebe Dorin

Older Woman

1 episode

Brian D. Phelan

Cute Guy

1 episode

William Borger

Crying Kid

1 episode

Roxana Ortega

Allison

1 episode

Steve Wilson

Foreman

1 episode

Carla Greene

Waitress

1 episode

Annette M. Lesure

Waitress

1 episode

Sayeed Shahidi

Little Boy

1 episode

Marsh Mokhtari

Mike

1 episode

Joni Kempner

Cameron

1 episode

Cooper Thornton

Instructor

1 episode

David Douglas

Barista

1 episode

Mary Alyce Kania

Waitress

1 episode

Barry Finkel

Funeral Director

1 episode

Laurie Okin

Mother

1 episode

Stefan Marks

Detective Harp

1 episode

Ty Barnett

Mugger

1 episode

Karlton Johnson

Policeman

1 episode

Tara Ochs

Waitress

1 episode

Michael Crider

Roth

1 episode

Ken Rudulph

Reporter

1 episode

Brent Tarnol

Jason

1 episode

John Taylor

Tommy Wylder

1 episode

Greg Cipes

Street Musician

1 episode

Terryn Westbrook

Female Fan #1

1 episode

Kathryn Taylor Smith

Female Fan #2

1 episode

Susie Geiser

Woman

1 episode

Amanda Collier

13-Year-Old Samantha

1 episode

Dondré Whitfield

Wes Green

1 episode

Robin Gwynne

Wife

1 episode

Christine Ebersole

Amy

1 episode

Florence Henderson

Loretta

1 episode

Nora Dunn

Cheryl

1 episode

Hahn Cho

Doctor

1 episode

Terrance Christopher Jones

Teacher

1 episode

Abdoulaye N'Gom

Minister

1 episode

Denise Gossett

Homeless Woman

1 episode

Indira G. Wilson

Photographer

1 episode

Charles C. Stevenson Jr.

Gentleman

1 episode

Angie Harmon

Gigi

1 episode

Bree Condon

Mickey

1 episode

Jackie Johnson

Jackie Johnson

1 episode

Shulie Cowen

Dolly

1 episode

Greg Callahan

Fake Dad

1 episode

David Trice

Baggage Service Rep

1 episode

Anna Zielinski

Ticket Agent

1 episode

Andre M. Johnson

Security Guard

1 episode

J.P. Gillain

Philippe

1 episode

Larry Reitzer

Duncan Weber

1 episode

Tony Jones

Police Sergeant

1 episode