Full cast of Once and Again

Sela Ward

Lily Manning

63 episodes

Billy Campbell

Rick Sammler

63 episodes

Jeffrey Nordling

Jake Manning

63 episodes

Susanna Thompson

Karen Sammler

63 episodes

Shane West

Eli Sammler

63 episodes

Julia Whelan

Grace Manning

63 episodes

Evan Rachel Wood

Jessie Sammler

63 episodes

Meredith Deane

Zoe Manning

63 episodes

Marin Hinkle

Judy Brooks

63 episodes

Todd Field

David Cassilli

63 episodes

Jennifer Crystal Foley

10 episodes

Kimberly McCullough

9 episodes

Mischa Barton

Katie Singer

8 episodes

Ever Carradine

8 episodes

Eric Stoltz

7 episodes

Paul Mazursky

7 episodes

Paul Dooley

6 episodes

David Clennon

6 episodes

Mark Feuerstein

5 episodes

Vanessa Lee Chester

5 episodes

Edward Zwick

5 episodes

Mark Valley

5 episodes

Rachel True

4 episodes

Patrick Dempsey

4 episodes

James Lafferty

4 episodes

Peter Schindler

4 episodes

James Eckhouse

3 episodes

Steven Weber

3 episodes

Robert Ri'chard

3 episodes

Adam Brody

3 episodes

Christina Chang

3 episodes

D. B. Sweeney

2 episodes

Jim Fyfe

2 episodes

Gina May

2 episodes

Jacob Smith

2 episodes

Saul Rubinek

2 episodes

John Lehr

2 episodes

Kay Lenz

2 episodes

Ellen Geer

2 episodes

Michael B. Silver

2 episodes

Alexandra Holden

2 episodes

Cory Hardrict

2 episodes

Archie Kao

2 episodes

Jane Sibbett

2 episodes

Josh Zuckerman

2 episodes

Regan Burns

2 episodes

D. B. Woodside

2 episodes

Suzanne Lanza

2 episodes

Michael Tucci

2 episodes

Steve Tyrell

2 episodes

Mary Faulkner

2 episodes

Laura Roth

Carter

2 episodes

Catherine McCord

1 episode

Ashley French

1 episode

Jenny Lewis

1 episode

Devon Odessa

1 episode

Deborah Van Valkenburgh

1 episode

Chris Olivero

Evan Fisher

1 episode

Josh Cooke

1 episode

Jennifer Sciole

1 episode

Melora Hardin

1 episode

Benito Martinez

1 episode

Jonathan Goldstein

1 episode

Molly Cheek

1 episode

Leighton Meester

Amanda

1 episode

Kristin Richardson

1 episode

Dyllan Christopher

1 episode

Glenn Morshower

1 episode

Susie Park

1 episode

Julianna McCarthy

1 episode

Tobin Bell

1 episode

LaTanya Richardson Jackson

1 episode

Marshall Herskovitz

1 episode

Shannon Sturges

1 episode

Jake Sandvig

1 episode

Edward Atterton

1 episode

Brenda Song

1 episode

Dennis Letts

1 episode

Joseph Malone

1 episode

Harley Jane Kozak

1 episode

Sherman Howard

1 episode

Fred Applegate

1 episode

Robert Prosky

1 episode

Arye Gross

1 episode

Riley Smith

1 episode

Richard Libertini

1 episode

Margaret Easley

1 episode

Heidi Marnhout

1 episode

Barbara Barrie

1 episode

Kiko Ellsworth

1 episode

Kimberly Scott

1 episode

John DeMita

1 episode

Kristina Anapau

1 episode

Bruce Weitz

1 episode

James Kyson

1 episode

Kyme

1 episode

Josh Coxx

1 episode

Brett Cullen

1 episode

Rosalind Chao

Tami Seitz

1 episode

Dempsey Pappion

1 episode

Lee Garlington

1 episode

Daniel Dae Kim

1 episode

Archie Hahn

1 episode

Ally Sheedy

1 episode

Lizzy Caplan

1 episode

Carlos Ponce

1 episode

Jeff Russo

1 episode

DeLauné Michel

1 episode

Trae Ireland

1 episode

Devon Gummersall

1 episode

Tim Haldeman

1 episode

Miriam Flynn

1 episode

Shelley Taylor Morgan

1 episode

Shonda Farr

1 episode

Elliott Francis

1 episode

Fred Ornstein

1 episode

Mark Daniel Cade

1 episode

Greta Sesheta

Nurse

1 episode

Jason Dohring

Coop

1 episode