Full cast of Desus & Mero

Desus Nice

Self - Host

180 episodes

The Kid Mero

Self - Host

180 episodes

Issa Rae

Self - Illustrious Guest / Self

3 episodes

Gabrielle Union

Self - Illustrious Guest

2 episodes

John David Washington

Self - Illustrious Guest / Self

2 episodes

Stacey Abrams

Self - Illustrious Guest

2 episodes

Seth Rogen

Self - Illustrious Guest

2 episodes

Don Cheadle

Self - Illustrious Guest

2 episodes

John Legend

Self - Illustrious Guest

2 episodes

Freddie Gibbs

Self

2 episodes

Alexandria Ocasio-Cortez

Self

2 episodes

Amy Poehler

Self - Illustrious Guest

1 episode

Vince Staples

Self - Illustrious Guest

1 episode

Ben Stiller

Self - Illustrious Guest

1 episode

2 Chainz

Self - Illustrious Guest

1 episode

Lupita Nyong'o

Self - Illustrious Guest

1 episode

Winston Duke

Self - Illustrious Guest

1 episode

Kirsten Gillibrand

Self - Illustrious Guest

1 episode

Carmelo Anthony

Self - Illustrious Guest

1 episode

Jordan Peele

Self - Illustrious Guest

1 episode

Anna Kendrick

Self - Illustrious Guest

1 episode

Cory Booker

Self - Illustrious Guest

1 episode

Lil Nas X

Self - Illustrious Guest

1 episode

Paul Scheer

Self - Special Appearance

1 episode

Charlize Theron

Self - Illustrious Guest

1 episode

Bill Hader

Self - Illustrious Guest

1 episode

Ava DuVernay

Self - Illustrious Guest

1 episode

Spike Lee

Self - Illustrious Guest

1 episode

Matt Walsh

Self - Illustrious Guest

1 episode

David Letterman

Self - Illustrious Guest

1 episode

Penn Badgley

Self - Illustrious Guest

1 episode

LaKeith Stanfield

Self - Illustrious Guest

1 episode

Kamala Harris

Self - Illustrious Guest

1 episode

Maxine Waters

Self - Illustrious Guest

1 episode

John Mulaney

Self - Illustrious Guest

1 episode

Barack Obama

Self - Illustrious Guest

1 episode

Killer Mike

Self - Illustrious Guest

1 episode

Missy Elliott

Self - Illustrious Guest

1 episode

Busta Rhymes

Self

1 episode

Diplo

Self

1 episode

Sheila E.

Self

1 episode

A$AP Ferg

Self

1 episode

Chris Rock

Self - Illustrious Guest

1 episode

RZA

Self - Illustrious Guest

1 episode

Sarah Cooper

Self - Illustrious Guest

1 episode

Yahya Abdul-Mateen II

Self - Illustrious Guest

1 episode

Ethan Hawke

Self - Illustrious Guest

1 episode

Jason Derulo

Self - Illustrious Guest

1 episode

Swizz Beatz

Self - Illustrious Guest

1 episode

Timbaland

Self - Illustrious Guest

1 episode

LL Cool J

Self - Illustrious Guest

1 episode

Tony Hawk

Self - Illustrious Guest

1 episode

Big Sean

Self - Illustrious Guest

1 episode

Janelle Monáe

Self - Illustrious Guest

1 episode

Jaden Smith

Self - Illustrious Guest

1 episode

Jaime Harrison

Self - Illustrious Guest

1 episode

Sue Bird

Self - Illustrious Guest

1 episode

Cori Bush

Self - Illustrious Guest

1 episode

Usain Bolt

Self - Illustrious Guest

1 episode

Stephen A. Smith

Self - Illustrious Guest

1 episode

Andy Samberg

Self - Illustrious Guest

1 episode

Eric André

Self - Illustrious Guest

1 episode

Judd Apatow

Self - Illustrious Guest

1 episode

Bubba Wallace

Self - Illustrious Guest

1 episode

Jon Stewart

Self - Illustrious Guest

1 episode

Jamaal Bowman

Self - Illustrious Guest

1 episode

Jesse Williams

Self - Illustrious Guest

1 episode

Dwyane Wade

Self - Illustrious Guest

1 episode

Katie Porter

Self - Illustrious Guest

1 episode

Billy Porter

Self - Illustrious Guest

1 episode

Spike Jonze

Self - Illustrious Guest

1 episode

Rashida Jones

Self - Illustrious Guest

1 episode

Jay Ellis

Self - Illustrious Guest

1 episode

Alicia Keys

Self - Illustrious Guest

1 episode

Joe Biden

Self - Illustrious Guest

1 episode

Mark Cuban

Self - Illustrious Guest

1 episode

Tracee Ellis Ross

Self - Illustrious Guest

1 episode

Malcolm Gladwell

Self - Illustrious Guest

1 episode

Alison Roman

Self - Illustrious Guest

1 episode

Anthony Fauci

Self - Illustrious Guest

1 episode

Demi Lovato

Self

1 episode

Seth Meyers

Self - Illustrious Guest

1 episode

Nick Kroll

Self - Illustrious Guest

1 episode

J Balvin

Self

1 episode

Andra Day

Self

1 episode

Glenn Close

Self

1 episode

Kenan Thompson

Self

1 episode

24kGoldn

Self

1 episode

Eddie Murphy

Self

1 episode

Phoebe Bridgers

Self

1 episode

Eddie Huang

Self

1 episode

Delroy Lindo

Self

1 episode

Ramy Youssef

Self

1 episode

Travis "Taco" Bennett

Self

1 episode

Kelly Rowland

Self

1 episode

Ludacris

Self

1 episode

Anthony Mackie

Self

1 episode

Zendaya

Self

1 episode

Whoopi Goldberg

Self

1 episode

Jazmine Sullivan

Self

1 episode

Travon Free

Self

1 episode

Julian Edelman

Self

1 episode

Taylour Paige

Self

1 episode

Yo-Yo Ma

Self

1 episode

Ziwe

Self

1 episode

Rashida Tlaib

Self

1 episode

Bobby Shmurda

Self

1 episode